Dr. Chung’s clinical practice includes the treatment of primary CNS malignancies, brain metastases and breast cancer. Her primary research interests have focused on personalized image-guided approaches for the management of brain tumors and metastases.
With a translational approach, her preclinical work has included the investigation of conformal radiation in combination with targeted anti-angiogenic therapy in a murine intracranial brain tumor model with serial multiparametric MRI and biofluid measures to discover promising biomarkers of response to guide personalized treatment of brain tumors. The findings from this preclinical work has led to several ongoing clinical trials evaluating serial MRI biomarkers in patients treated with radiosurgery as well as a Phase I dose-escalation trial of anti-angiogenic agent (Sunitinib) in concurrently with radiosurgery. In terms of image-guided therapy, Dr. Chung has also lead the early clinical evaluation of a novel image-guided Gamma Knife radiosurgery unit that incorporates cone-beam CT and infrared intrafraction motion-monitoring.
Dr. John Fiveash currently serves as the Vice Chair for Academic programs at the University of Alabama at Birmingham. As a radiation oncologist specializing in the treatment of central nervous system tumors, he is involved in clinical trials for primary and secondary malignant brain tumors. His group has been conducting pre-clinical studies of single isocenter, multiple target radiosurgery for over a decade.
"My research interests include clinical trials of novel therapeutics in combination with radiation therapy particularly in the treatment of brain and prostate tumors. In addition, I have been very involved in treatment planning research and education for IMRT and IGRT. As residency director, I have established online educational opportunities for residents and students to better enable more efficient learning."